Cancer and chronic kidney disease rates among Canada’s First Nations, Inuit and Métis people are increasing faster than overall rates for Canada, yet at the community level, there remains a lack of awareness about the causes of cancer and chronic kidney disease. This course examines the need for culturally relevant education to improve First Nations, Inuit and Métis disease awareness, prevention and care. The course also analyzes the role that factors such as geography, distance and access to basic health services, jurisdictional issues and trust play in some of the rural and remote communities where many of Canada’s First Nations, Inuit and Métis people reside.